Two points define one line. To find an angle between two lines you need another line stated either explicitly or implicitly. The lisp function angle assume implicitly that the "other" line is the x axis. What assumption would you like to make about the other line if only given two points?
A program could output, for example, the angles between the line defined by two points with the world X axis, Y axis and Z axis. It could also output the angle with it projection onto one of the principal planes (e.g., the XY plane) or... What do you need? Be as detailed as possible.